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Paul Lehner is the Sheila Joan Smith Professor of Immunology at the University of Cambridge, where he focuses on novel genes and intracellular pathways involved in virus-host interactions, with particular emphasis on epigenetic mechanisms of viral silencing. His group discovered the human silencing hub (HUSH) complex, an epigenetic transcriptional repressor that serves as a genome-wide surveillance mechanism, defending the genome against retroelement attacks. Dr. Lehner is an infectious diseases physician whose research aims to understand how cells counteract DNA invasions that threaten genomic integrity. His work has revealed that DNA silencing through chromatinization is a likely default pathway against viral elements. Moreover, Dr. Lehner's research delves into how viruses evade immune recognition through hijacking host cellular machinery. He has identified cellular receptors targeted by viruses and developed functional genetic and proteomic technologies to investigate these interactions.
University of Cambridge • Cambridge, UK
Leading research in the field of immunology focusing on virus-host interactions.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.