Dr. Paul Lyons

Biography

Paul Lyons is a researcher involved in the application of high-throughput genomic approaches to the study of autoimmune diseases. He plays a significant role in the establishment of the Cambridge Hinxton Centre for Translational Research in Autoimmune Disease, collaborating with clinicians, basic scientists, and bioinformaticians. His work focuses on applying expression profiling to clinical management, particularly for conditions such as systemic lupus erythematosus and small vessel vasculitis. Lyons has developed an optimized cell selection strategy that enables the expression profiling of purified leukocyte subsets isolated from patients with active disease, both before and after treatment. This approach aims to facilitate the development of novel biomarkers that can be utilized to stratify patients, select appropriate treatment protocols, monitor patient responses, and predict relapses. Additionally, his research provides insights into the molecular pathogenesis of autoimmune diseases.

Research Interests