Dr. Paul Modrich

Biography

Paul Modrich is a distinguished biochemist known for his pioneering research in the field of DNA repair mechanisms, particularly mismatch repair. He served as a James B. Duke Distinguished Professor Emeritus at Duke University and was awarded the Nobel Prize in Chemistry in 2015 for his work elucidating the molecular mechanisms that enable cells to repair damaged DNA. His research has significantly advanced our understanding of genetic stability, specifically how cells correct DNA biosynthetic errors and prevent mutations that could lead to cancer. He has also studied the role of mismatch repair in human cells and its implications for hereditary nonpolyposis colon cancer. Modrich's lab has made remarkable contributions to the field, including the reconstitution of pure bacterial mismatch repair systems in vitro, which has shed light on the reactions and interactions of various proteins involved in DNA repair. Modrich's dedication to science extends beyond his research; he has actively participated in educational and professional activities, including serving on scientific advisory boards and contributing to cancer research initiatives.

Research Interests

Experience