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Paul van Bergen en Henegouwen is an Associate Professor at Utrecht University, specializing in therapeutic and diagnostic applications of antibody fragments. His research primarily focuses on single-domain antibodies, also known as nanobodies, which are derived from Llama glama antibodies. These nanobodies, with a molecular weight of approximately 15 kDa, exhibit high affinity for diverse targets. Through phage display techniques, they can be functionalized for direct conjugation with fluorophores, toxins, and nanoparticles. In addition to his academic role, he serves as a consultant for companies engaged in the development of nanobody-based therapeutics, including nanobody-drug conjugates and strategies for targeted protein degradation. His contributions significantly enhance the delivery systems for therapeutics aimed at brain applications.
Department of Psychology