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Paula graduated in Biochemistry from the Faculty of Sciences at the University of Lisbon, Portugal, and obtained her PhD in Biochemistry from the University of London, UK, with studies at Imperial College of Science, Technology and Medicine. She held postdoctoral positions at Imperial College School of Medicine and at the Institute of Cancer Research in London. In 2013, Paula moved to Cambridge, UK, to start her own research group at the MRC Laboratory of Molecular Biology. In April 2020, she relocated her group to the University of Glasgow, where she holds the position of Professor of Cryo-Electron Microscopy. Paula's PhD studies focused on regulatory protein complexes primarily using electron microscopy-based methods. Her current work revolves around studying the structure and function of eukaryotic proteasome complexes, with an emphasis on fully understanding human variants. Additionally, she investigates the use of high-resolution cryo-EM in the development of new therapeutic drugs, contributing to the validation of the Plasmodium proteasome as a potential target for antimalarials. Her research aims to fully characterize the human proteasome, which is essential for continuous protein turnover in cells, impacting processes like cell cycle progression, DNA repair, and apoptosis.
University of Glasgow • Glasgow, UK
Leading research on eukaryotic proteasome complexes, focusing on electron microscopy methods.