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Paula M. Oliver is an Associate Professor in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania. Her research focuses on defining new mechanisms that regulate immune cell activation and protective immune responses, with the goal of using this information to design therapies for treating immune-mediated pathologies, such as autoimmune and allergic diseases. The research explores how immune cells collaborate to remove invading organisms while minimizing collateral damage. Immune cells adapt to external stimuli by adjusting levels of key regulatory proteins and modulating their activity states. A significant area of her work involves the study of the ubiquitin-proteasome system, particularly the role of E3 ubiquitin ligases in controlling immune cell fates. Dr. Oliver has identified autonomously regulated membrane tethered adaptors that activate E3 ubiquitin ligases and has determined their roles in T cell activation and differentiation. Her lab employs systems biology approaches that integrate transcriptomic, proteomic, and ubiquitomic data to identify active E3 ligases in T cells.
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