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Paula Watnick is a professor in the field of Pediatrics at Boston Children's Hospital. Her lab conducts fundamental and translational studies aimed at understanding and treating infections caused by intestinal bacteria. Her key research interests encompass the interactions between intestinal pathogens and host metabolism, particularly in the context of diarrheal diseases that significantly contribute to malnutrition in developing countries. Watnick's team employs both invertebrate and vertebrate models to examine how diarrheal pathogens modulate host nutrient utilization. Additionally, she investigates the development of biofilm matrix-based antigen and enzyme delivery platforms, leveraging surface-adherent biofilms composed of polysaccharides and lectins for oral delivery systems. Furthermore, she is focused on discovering novel therapeutic natural products to combat multi-drug resistant bacteria, utilizing a high-throughput, whole-cell metabolic screening approach to identify active compounds against these pathogens.
Boston Children's Hospital • Boston, MA
Conducts research and oversees studies on infections caused by intestinal bacteria.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).