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Peter S. Choi, Ph.D. is an Assistant Professor in the Department of Pathology Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania. Dr. Choi's research focuses on understanding the genetic alterations that affect RNA splicing processes in cancer, exposing potential therapeutic vulnerabilities. His laboratory investigates the role of RNA-binding proteins and their mutations in cancer, particularly how alternative splicing contributes to tumorigenesis. Dr. Choi utilizes next-generation sequencing and genome editing technologies, including CRISPR/Cas9, to explore the functional impact of aberrant splicing and to identify specific dependencies of cancer genotypes. With a strong focus on the complexities of gene regulation, his work aims to unravel the landscape of splicing factors and their relevance in cancer, thereby contributing to the search for novel therapeutic strategies.
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