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Peter Janes is an Associate Professor (Research) at Monash University, leading the Protein Interaction Cancer Lab. His principal research interest lies in the role of cell surface proteins in promoting tumor growth, particularly in the context of the tumor microenvironment and the development of targeted therapeutic antibodies. Janes focuses on Eph receptor tyrosine kinases due to their crucial roles in tumor tissue patterning and stem cell maintenance. His research employs biochemical and structure/function imaging techniques using various tumor models, both in vitro and in vivo. Notably, Janes has worked with antibodies targeting EphA3 and ADAM10, which inhibit tumor growth in mice, and he is currently advancing an EphA3 antibody that is entering Phase II clinical trials. His research aligns with the UN Sustainable Development Goals, and he has experienced significant collaborations in top research areas over the past five years including projects targeting antibody therapy for malignant mesothelioma and drug-resistant breast cancers.
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