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Peter Påhlsson is a Professor at Linköping University. His research focuses on disease-associated changes in glycosylation, highlighting the structural variability of carbohydrate chains attached to proteins. His work explores the biological roles of carbohydrate modifications, particularly in inflammation, where carbohydrates act as ligands for selectins to recruit leukocytes to activated endothelium. Peter is investigating how chronic inflammatory diseases and malignancies produce altered glycosylation patterns in both secreted and membrane-bound glycoconjugates. By monitoring specific changes in glycosylation on membrane-associated plasma proteins in patients with chronic inflammatory diseases, he aims to understand the relationship between glycosylation patterns and the inactivation of specific glycosyltransferases. His research also includes developing immunochemical, chromatographic, and mass spectrometric methods to analyze glycosylation for the diagnosis of inflammatory diseases and those affecting the liver. Additionally, he studies the role of increased fucosylation of alpha 1-acid glycoprotein in regulating the inflammatory response and has identified inactivating mutations in fucosyltransferase VII in patients with chronic inflammatory conditions. His research interests extend to structural and functional studies of glycoglycerolipids in colon carcinoma.
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