Dr. Peter Parham

Biography

Peter Parham is a Professor in Structural Biology at Stanford University, with a courtesy appointment in Microbiology and Immunology. His research focuses on the biology, genetics, and evolution of Major Histocompatibility Complex (MHC) class molecules and natural killer (NK) cell receptors, which are critical components of the immune system. The Parham laboratory investigates how classical MHC class molecules interact with receptors on cytolytic CD8+ T lymphocytes and NK cells to mediate immune responses against viral infections. His work reveals the rapid evolution of viruses and its impact on MHC class diversity, which presents a significant immunological barrier in tissue transplants from unrelated donors. Parham's research also extends to the clonal diversity of NK cells and their role in innate immunity, addressing the polymorphism of NK receptor genes shaped by historical pathogen encounters. He examines the coevolution of MHC class and NK receptor genes in humans and their close relatives, aiming to understand the molecular interactions that determine NK cell receptor effectiveness. His studies also target the clinical consequences of NK cell receptor diversity, particularly in the context of leukemia and lymphoma treatments.

Research Interests

Courses