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Peter Savage is a Professor at the University of Chicago in the Department of Pathology. His research focuses on the regulation of immune tolerance and anti-tumor immunity. His major projects involve the development and function of tumor-associated regulatory T cells (Tregs), particularly the role of Foxp3+ Tregs in autoimmune regulation and immune homeostasis in human cancers. He investigates the developmental origins and antigen specificity of thymus-derived Tregs, and explores how Tregs respond to self-antigens, seeking to understand their biology in the context of cancer. He has collaborated with Dr. Erin Adams to identify ligands recognized by Tregs in mouse models, with findings suggesting that Treg responses converge on self-proteins susceptible to autoimmune attack. His work also examines the role of dendritic cells in Treg development and immune regulation, demonstrating their pivotal role in presenting self-antigens necessary for Treg function.
Department of Philosophy