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Professor Peter Wells' laboratory focused on the molecular mechanisms of drug toxicities and diseases caused by the enzymatic bioactivation of relatively non-toxic drugs. Over a research career spanning 45 years, his work emphasized the role of reactive intermediates and reactive oxygen species (ROS) in irreversibly damaging proteins and DNA. Professor Wells' early research revealed that glucuronidation processes could reduce the toxicity of xenobiotics, such as drugs and environmental chemicals, by diverting these substances from bioactivation pathways that lead to toxic reactive intermediates. His studies have shown that the balance of enzymatic pathways that produce ROS versus those involved in detoxification critically influences individual susceptibility to various toxicities and diseases, including neurodegeneration and developmental disorders. Moreover, his lab's findings have highlighted the prenatal impacts of ROS on DNA damage and gene expression alterations, suggesting potential for postnatal treatments for neurodevelopmental disorders. Professor Wells has published extensively in premier journals covering molecular pharmacology and toxicology, contributing significantly to our understanding of the fields.
Leslie Dan Faculty of Pharmacy, University of Toronto • Toronto, Ontario, Canada
Conducted research in molecular toxicology with a focus on the interaction of drugs and environmental chemicals with biological systems.
Department of Sociology