Dr. Phil Biggin

Biography

Phil Biggin is a Professor of Biochemistry at the University of Oxford, where he specializes in the development of computational methods to investigate receptor dynamics and ligand-binding characteristics of proteins, particularly those in the brain. His research focuses on understanding the conformational changes that receptor proteins undergo when interacting with small molecules, which has significant implications for designing therapies for conditions such as Alzheimer's disease, epilepsy, and Parkinson's disease. Utilizing molecular dynamics simulations, Phil aims to generate detailed representations of atomic movements and energetics within biological systems, which can lead to high-quality predictions of how tightly compounds may bind to their targets. These insights are critically important for rational drug-design programs working to improve therapeutic outcomes.

Research Interests