Dr. Philipp Mews

Biography

Philipp Mews is an Assistant Professor in the Department of Physiology & Biophysics at Boston University’s Chobanian & Avedisian School of Medicine. His research focuses on the interplay of metabolic signals and epigenetic plasticity in the brain, influencing cognition, memory, and behavior across the lifespan. His key research interests include neuroepigenetics and the study of substance use disorders, aiming to delineate how metabolic states affect chromatin dynamics and consequently gene expression within neurons. Mews’s work in the realm of addiction dives into the molecular alterations that occur during and after substance exposure, seeking to identify therapeutic targets that may help mitigate the risk of relapse. He also investigates the relationship between metabolism and memory formation and persistence, particularly in the hippocampus—crucial for learning and memory. Aging and neurodegeneration represent another frontier in his research, where he explores how age-related metabolic dysfunction affects epigenetic stability and neuronal function. Mews's lab utilizes a multi-scale approach, employing genomic, epigenomic, and proteomic techniques alongside behavioral studies to dissect the metabolic signaling pathways that regulate neuronal function. He encourages motivated students and researchers to join his lab for a rigorous exploration of these critical neuroscientific inquiries.

Research Interests