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Phillip Sharp is a prominent Institute Professor at the Massachusetts Institute of Technology (MIT) in the Department of Biology, currently serving as an emeritus faculty member at the Koch Institute. His research has significantly contributed to the understanding of gene expression in mammalian cells, including the transcription processes and roles of non-coding RNAs, as well as RNA splicing. Sharp's noteworthy investigation into small, non-coding RNAs, specifically microRNAs (miRNAs), has shed light on their regulatory impact on genes during various stages of mRNA translation and stability. Moreover, he explores the mechanisms underlying transcription, including divergent transcription and its correlation with RNA splicing and chromatin modifications. Sharp’s extensive contributions to biomedical science have garnered him recognition, including the Nobel Prize in Physiology or Medicine in 1993 and the National Medal of Science in 2004.