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Prof. Pierre Maechler focuses on mitochondria energy metabolism, exploring how mitochondria generate metabolic signals and control glucose recognition and insulin exocytosis. His research examines various aspects of mitochondrial function, including the generation and intracellular transport of glutamate and its action in beta-cells of the brain, contributing to energy homeostasis. He has a particular interest in the Glud1 gene, which encodes glutamate dehydrogenase, studying its role through tissue-specific knockouts and activating mutations leading to conditions like hyperinsulinemia in beta-cells, hyperammonemia in the liver, and epilepsy in the brain. His pioneering work enriches the understanding of metabolic regulation and its implications for health and disease.
Includes Department of Management, Finance, Economics, and Statistics programs. GMAT is strongly encouraged but not mandatory for most GSEM masters.