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Piotr Sliz is an Associate Professor in the Department of Pediatrics at Harvard Medical School. His laboratory focuses on structural biology and computational studies to understand the mechanisms of diseases by elucidating reaction mechanisms, contributing to the development of effective functional probes and small molecule inhibitors. His work involves X-ray crystallography to determine high resolution atomic structures of proteins and RNAs, facilitating an interface between structural biology and computational methodologies. Key research interests include mechanistic studies of Lin28, a microRNA biogenesis regulator and reprogramming factor. He has determined high resolution crystal structures of Lin28 complexes with microRNAs and is exploring fundamental principles of protein-RNA interactions to develop small molecule probes. Additionally, he studies the macromolecular complexes involved in microRNA biogenesis pathways, particularly focusing on how interactions with Lin28 inhibit the maturation of let-7 microRNAs. Sliz is also involved in leveraging cloud computing resources to accelerate structure determination, contributing to a global infrastructure that supports hundreds of structural biology laboratories.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.