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Pnina Brodt, Professor at McGill University, focuses her research on cancer metastasis, particularly the molecular events underlying liver metastasis. Her team has revealed how inflammatory responses play a critical role in the early stages of liver metastasis and how an inflammatory microenvironment can promote metastasis in colorectal and lung cancers. Brodt's work has significantly contributed to identifying the insulin-like growth factor (IGF) axis’s role in cancer invasion and metastasis, leading to strategies aimed at blocking the IGF-I axis through bio-engineered IGF-Trap, currently in development as an anti-cancer drug. She is a co-leader of the Cancer Axis Research Institute at the McGill University Health Center and co-founder of the Liver Metastasis Research Network, which is an international, multidisciplinary initiative devoted to uncovering the molecular mechanisms of liver metastasis to improve patient care.
Department: Department of Medicine. Program: Experimental Medicine.