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The Sivaramakrishnan Lab at the University of Pennsylvania focuses on the mechanisms that determine cell identities during embryonic development, leveraging the C. elegans model to explore transcriptional regulation and developmental dynamics. The lab investigates how transcription rates and mRNA output can maintain consistency in cell fate decisions and how size-dependent factors influence the transcriptional landscape of embryonic cells. Additionally, they study the implications of transcriptional dysregulation on developmental disorders, aiming to uncover the molecular underpinnings of such conditions. The lab fosters a collaborative environment, encouraging diverse scientific inquiries and open discussion among researchers.
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