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Qing R. Fan is a Professor at the Vagelos College of Physicians and Surgeons, affiliated with Columbia University. He holds a PhD, MA, and BA in Chemistry from Harvard University. His research focuses on the molecular mechanisms of class C G protein-coupled receptors (GPCRs), particularly their role in transmitting signals across biological membranes. Class C GPCRs are instrumental in various biological processes, including neurotransmission and calcium homeostasis. Professor Fan's work investigates the structure and function of these receptors, including the human GABA(B) receptor and calcium-sensing receptor (CaS). He has determined the extracellular-domain structures of the GABA(B) receptor in multiple functional states and has provided insights into its ligand recognition and activation mechanisms. His research has revealed novel interactions and structural features crucial for receptor function and integrity, emphasizing the complex interplay between amino acids and ions in regulating GPCR activity. Professor Fan's contributions to the field significantly advance our understanding of GPCR biology and their therapeutic potential.
Exact Department Name: Department of Physiology and Cellular Biophysics. Program: Cellular and Molecular Physiology & Biophysics.