Dr. Quentin Thomas

Biography

Quentin Thomas is affiliated with the University of Copenhagen, where he conducts research on transcriptional integrity and its critical role in cellular functions, specifically focusing on mRNA transcripts as the basis for protein products. His work centers on RNA polymerase II (RNAPII), which is responsible for the transcription of the vast majority of protein-coding genes and numerous non-coding RNAs. Thomas studies the co-transcriptional processing of nascent RNA transcripts that is dependent on the C-terminal domain (CTD) of RNAPII, which consists of a repeated consensus sequence that plays a crucial role in transcription regulation. His group aims to understand the fundamental biological mechanisms underlying transcriptional regulation, processing of nascent RNA in mammalian cells, and how misregulation can contribute to diseases such as cancer. He is particularly interested in the proteins that interact with CTD RNAPII and their impact on the maturation of nascent RNA transcripts.

Research Interests