Professor Dr. Rachel Klevit

Biography

Rachel Klevit is the Edmond H. Fischer/Washington Research Foundation Endowed Chair and a Professor of Biochemistry at the University of Washington. Her research focuses on understanding molecular recognition, particularly the role of protein-protein interactions in human disease. She utilizes a variety of structural, biochemical, molecular biological, and biophysical techniques with a major emphasis on high-resolution NMR spectroscopy and mass spectrometry. Ongoing projects within her research group explore critical systems such as BRCA1, a breast cancer susceptibility protein, and the mechanisms of ubiquitination. The group also studies small heat shock proteins including αB-crystallin and HSP27, which are pivotal in maintaining protein solubility under stress. Additional research involves the PhoQ regulatory system in pathogenic bacteria, examining structural strategies relevant to bacterial virulence. Klevit's efforts aim to address fundamental questions about the structure and function of these important biomolecules, contributing significant insights into the biological processes behind diseases.

Research Interests

Experience