Dr. Raju Kucherlapati

Biography

Raju Kucherlapati is the Paul C. Cabot Professor of Genetics at Harvard Medical School. His research focuses on Human Genetics, particularly the cloning of human disease genes and understanding the mutations in individual genes that cause human diseases. He has a keen interest in Noonan syndrome, an autosomal dominant disorder caused by mutations in the RAS-MAP Kinase pathway, and is dedicated to identifying additional genes and mutations associated with this syndrome using whole-genome and exome sequencing technologies. Furthermore, Kucherlapati has established mouse models to study the molecular etiology of Noonan syndrome and to develop therapeutic strategies. His long-standing research program also delves into the genetics of colorectal cancer, employing genetic engineering to model the initiation and progression of gastrointestinal cancer by manipulating a variety of genes suspected of involvement. His contributions extend to efforts with The Cancer Genome Atlas (TCGA), where he has aided in the collection and analysis of genetic data from a vast array of tumors, applying high throughput genomic sequencing technologies to uncover chromosomal aberrations associated with various tumor types.

Research Interests