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Randall Wharton King is the Harry C. McKenzie Professor of Cell Biology at Harvard Medical School, where he conducts research focused on understanding the fundamental principles of cell biology to develop new approaches for treating human disease. His work emphasizes the regulation of the ubiquitin-proteasome pathway and cell division processes. Specifically, he investigates how steps in cell division, particularly the transition from metaphase to anaphase, involve the degradation of proteins that regulate chromosome cohesion. His laboratory utilizes high-throughput screens in Xenopus extracts to identify compounds that disrupt ubiquitin-dependent degradation and to explore these compounds as potential anti-cancer agents. He has collaborated with the Finley lab at Harvard Medical School to characterize the role of the proteasome-associated deubiquitinating enzyme Usp14. His findings have highlighted new methods for treating diseases related to protein misfolding and neurodegeneration, and he is interested in developing high-throughput technologies for identifying drug targets, including RNA interference technologies and long-term time-lapse imaging.
Harvard Medical School • Boston, MA
Teaching and conducting research in cell biology.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.