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The Moon lab was principally interested in the mechanisms underlying the formation of mesoderm and central nervous system in vertebrate embryos. Since the late 1980s, Randall Moon’s research has focused on the Drosophila segment polarity gene wingless, which encodes a secreted intercellular signaling polypeptide. His findings related to the mouse proto-oncogene Wnt-1 showed that misexpression in Xenopus embryos led to a duplication of the embryonic axis, which provided strong evidence for Wnt-1 as a signaling factor. The lab explored the existence, expression, activities, and potential functions of the Wnt gene family in Xenopus and zebrafish. It investigated the roles of Wnts in embryonic processes and their modulation of signal transduction pathways, examining cellular responses to Wnt signals in real-time to understand how these signals affect developmental processes. The primary projects centered on Wnt signaling pathways, physiological responses to Wnt signals, and their roles in cell fate specification during embryonic development.
University of Washington • Seattle, WA
Retired but remains active in research.
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