Dr. Rasmus Bak

Biography

Rasmus Bak is an Associate Professor at Aarhus University with a strong background in developing strategies that apply novel techniques in genome engineering of human cells. With over 17 years of research experience, he has worked extensively in gene therapy for genetic diseases and in immuno-oncology. His expertise encompasses a wide range of gene expression vectors including plasmids, transposons, lentiviral vectors, and adeno-associated viral vectors. Additionally, he is well-versed in CRISPR/Cas-based platforms, working on knockout, knockin, gene replacement, and transcriptional regulation issues, as well as base and prime editing techniques. Bak's work on chemically modified guide RNAs utilizing the CRISPR/Cas9 system has shown significant promise in facilitating high levels of genome editing in primary human hematopoietic stem progenitor cells. He has successfully developed a potent CRISPR/Cas9-based genome editing strategy for Sickle Cell Disease and demonstrated the system's ability to support large transgene integration through sequential homologous recombination. Furthermore, he is engaged in developing precision tools for manipulating gene transcription, and has actively contributed to the field with notable publications in high-impact journals.

Research Interests

Experience

Awards