Dr. Raymond Trievel

Biography

Raymond C. Trievel is a Professor in the Department of Biological Chemistry at the University of Michigan Medical School. His research focuses on structural biochemistry, particularly the roles of histone modifying enzymes in epigenetic regulation. His lab employs a variety of biochemical approaches to study enzymatic mechanisms and substrate specificities of human histone modifying enzymes, including lysine methyltransferases and demethylases. Dr. Trievel has initiated a research program to understand the functions of histone modifying enzymes expressed by bacterial pathogens, which constitutes a novel intersection between microbiology and chromatin biology. His work is instrumental in elucidating host-pathogen interactions at the molecular level. Dr. Trievel's notable contributions include investigations into AdoMet-dependent methyltransferases and their unique interaction mechanisms, enhancing our understanding of enzyme catalysis. He received his PhD from the University of Pennsylvania and has held various prestigious positions, including at the National Institutes of Health. His recent publications address critical aspects of methyltransferase functions and their implications in biological processes, reflecting years of rigorous research and academic excellence.

Research Interests