Dr. Rebecca Simmons

Biography

Rebecca Simmons, M.D. is a Hallam Hurt Professor in the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Her research primarily focuses on elucidating the molecular mechanisms linking fetal growth retardation (IUGR) to the development of obesity and type 2 diabetes in adulthood. Dr. Simmons has initiated several major and minor projects, with significant emphasis on understanding how oxidative stress contributes to β-cell dysfunction and insulin resistance. By developing animal models, she has demonstrated that fetal growth retardation triggers mitochondrial dysfunction and oxidative stress, leading to long-term metabolic issues. One of her pivotal findings is that neonatal treatment with Exendin-4 prevents diabetes in IUGR rats by restoring normal β-cell function and mass. Dr. Simmons's work also explores the epigenetic modifications of genes associated with β-cell development influenced by the intrauterine environment, particularly how obesity during pregnancy affects offspring's obesity risk. Through her innovative studies, she has revealed potential therapeutic targets for mitigating the adverse effects of IUGR and maternal obesity on future generations.

Research Interests

Experience