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Rebecca G. Wells is a Professor in the Department of Medicine (Gastroenterology) at the Perelman School of Medicine at the University of Pennsylvania. She holds an M.D. from Johns Hopkins University (1987) and a B.S. in Molecular Biophysics Biochemistry from Yale University (1983). Her research focuses on the mechanisms of hepatic fibrosis and the role of dysregulated hepatic cell populations in liver diseases. Wells explores liver mechanics, particularly how liver stiffness correlates with fibrosis and pathogenetic mechanisms associated with conditions like biliary atresia. She is involved in novel investigation approaches, studying cell-matrix interactions and the biology of myofibroblast precursor populations under conditions of liver injury. Her work incorporates aspects of engineering and biology to advance understanding of liver diseases, with a specific emphasis on the contributions of mechanical factors and extracellular matrix components to fibrosis development. Dr. Wells' research has implications for understanding and treating hepatocellular carcinoma as well as conditions resulting from biliary fibrosis.
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