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Reza Sharif-Naeini is a Professor in the Department of Physiology at McGill University. His research focuses on neurophysiology, particularly the molecular bases of mechanotransduction and the role of mechanosensory neurons in normal and pathological pain transmission. Understanding mechanotransduction, the process by which cells convert mechanical stimuli into electrical signals, is crucial for physiological functions such as the senses of touch and pain, as well as regulating hydromineral homeostasis and baroreflex functions. Sharif-Naeini’s lab investigates mechanosensitive ion channels, which are membrane proteins implicated in these processes, aiming to identify their molecular identities and mechanisms of activation. This knowledge is essential for developing new therapeutic strategies for chronic conditions related to the nervous and cardiovascular systems. His current projects include identifying the molecular mechanisms involved in neuronal mechanotransduction and the central neuronal circuits engaged in chronic pain control.
Department: Department of Medicine. Program: Experimental Medicine.