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Rich Halberg is a Professor at the McArdle Laboratory for Cancer Research at the University of Wisconsin-Madison. His research focuses on colorectal cancer, which is a leading cause of cancer death in the United States. His work investigates the heterogeneity of cancer cells within tumors, exploring how these differences impact prevention and treatment. Halberg's laboratory has presented evidence that colorectal cancers can arise from both monoclonal and polyclonal origins. He has demonstrated that hereditary and sporadic colorectal tumors in humans can be derived from multiple progenitors, providing insight into the mechanisms of tumor formation and the role of mutations in generating tumor subpopulations. Halberg's studies include the understanding of intratumoral heterogeneity, identifying the sources of this variation, and how it influences clinical outcomes. With distinct models to explain polyclonality in tumors, his findings challenge established beliefs in cancer biology, proposing that solid tumors begin as polyclonal formations due to genetic and microenvironmental influences. His research ultimately seeks to inform better strategies for cancer prevention and treatment.
Department: Department of Computer Sciences