Dr. Richard Kolesnick

Biography

Richard N. Kolesnick, MD, leads a laboratory at Sloan Kettering Institute focusing on the role of sphingolipid signaling in the stress response. His research investigates how alterations in sphingolipid metabolism, specifically ceramide generation and sphingomyelin degradation, influence cellular responses to various physiological and pharmacological stresses such as heat, radiation, and chemotherapy. Dr. Kolesnick's work provides insights into the pathways that dictate cell survival versus apoptosis under stressful conditions, aiming to elucidate mechanisms underlying tumor regression and vascular dysfunction associated with radiation exposure. He is recognized for his contributions to understanding the complex signaling networks involved in these processes and their implications for developing therapeutic strategies in cancer treatment.

Research Interests

Experience