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Dr. Richard Manderville is a Professor of Chemistry and Toxicology at the University of Guelph, specializing in biochemical toxicology and the impact of DNA adducts on cellular processes. His research primarily focuses on the structural and biological effects of C8-aryl-2′-deoxyguanosine adducts, which are common lesions that manifest in DNA through various linkages. He investigates the mutagenic properties of these lesions and their propensity to induce genetic mutations, such as two-base deletions. His laboratory employs synthetic organic chemistry methods to create modified oligonucleotides for studying the interactions between DNA and these adducts. Manderville also conducts research on fluorescent biosensors that utilize modified DNA aptamers to detect molecular targets by monitoring changes in fluorescence related to DNA conformational shifts. His work is pivotal in advancing the field of molecular toxicology and offers opportunities for students interested in biochemistry and organic chemistry. Dr. Manderville has published extensively in his research areas and consistently encourages student participation in ongoing projects.
University of Virginia • Charlottesville, Virginia, U.S.A.
Conducted research in BioOrganic Chemistry under Sidney M. Hecht.
Wake Forest University • Winston-Salem, North Carolina, U.S.A.
Taught and conducted research in Chemistry.
Wake Forest University • Winston-Salem, North Carolina, U.S.A.
Advanced research in Chemistry and contributed to departmental development.
University of Guelph • Guelph, Canada
Researched and taught in the Department of Chemistry.
University of Guelph • Guelph, Canada
Current position focusing on Chemistry and Toxicology.
Toxicology Program, University of Guelph • Guelph, Canada
Oversees the Toxicology Program at the university.
Department of Clinical Studies. Offers MSc by thesis (2 years) and MSc by coursework (1 year).