Professor Dr. Richard Manderville

Professor

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Biography

Dr. Richard Manderville is a Professor of Chemistry and Toxicology at the University of Guelph, specializing in biochemical toxicology and the impact of DNA adducts on cellular processes. His research primarily focuses on the structural and biological effects of C8-aryl-2′-deoxyguanosine adducts, which are common lesions that manifest in DNA through various linkages. He investigates the mutagenic properties of these lesions and their propensity to induce genetic mutations, such as two-base deletions. His laboratory employs synthetic organic chemistry methods to create modified oligonucleotides for studying the interactions between DNA and these adducts. Manderville also conducts research on fluorescent biosensors that utilize modified DNA aptamers to detect molecular targets by monitoring changes in fluorescence related to DNA conformational shifts. His work is pivotal in advancing the field of molecular toxicology and offers opportunities for students interested in biochemistry and organic chemistry. Dr. Manderville has published extensively in his research areas and consistently encourages student participation in ongoing projects.

Research Interests

Biochemical Toxicology Fluorescent Biosensors DNA Aptamers Synthetic Organic Chemistry

Experience

Postdoctoral Research Associate

— Present

University of Virginia • Charlottesville, Virginia, U.S.A.

Conducted research in BioOrganic Chemistry under Sidney M. Hecht.

Assistant Professor

— Present

Wake Forest University • Winston-Salem, North Carolina, U.S.A.

Taught and conducted research in Chemistry.

Associate Professor

— Present

Wake Forest University • Winston-Salem, North Carolina, U.S.A.

Advanced research in Chemistry and contributed to departmental development.

Associate Professor

— Present

University of Guelph • Guelph, Canada

Researched and taught in the Department of Chemistry.

Professor

— Present

University of Guelph • Guelph, Canada

Current position focusing on Chemistry and Toxicology.

Director

— Present

Toxicology Program, University of Guelph • Guelph, Canada

Oversees the Toxicology Program at the university.

Requirements for University of Guelph

Master Program

Requirements

GPA Requirement
Required:3
IELTS
Listening
Required:6
Reading
Required:6
Writing
Required:6
Speaking
Required:6
Overall
Required:6.5
TOEFL
Listening
Required:21
Reading
Required:21
Writing
Required:21
Speaking
Required:21
Total
Required:89

Prerequisites

Honours baccalaureate degree in a relevant field or DVM degree Identify a potential faculty advisor

Application Checklist

  • Online application
  • Official transcripts
  • Two academic reference assessments
  • Statement of interest
  • English language proficiency test results (if applicable)

Specialization Notes

Department of Clinical Studies. Offers MSc by thesis (2 years) and MSc by coursework (1 year).