Dr. Richard Sherwood

Biography

Dr. Richard Sherwood is an Assistant Professor in the Biological Biomedical Sciences program. His research primarily focuses on the application of high-throughput experimental assays and computational algorithms to predict genotypic outcomes from CRISPR/Cas9 genome editing. His work has highlighted the predictable nature of CRISPR/Cas9 outcomes, particularly in relation to human pathogenic indel mutation sites, and he is devoted to improving the precision of CRISPR/Cas9 editing through the development of novel genomic screening platforms. Furthermore, Dr. Sherwood is engaged in creating predictive computational models for transcription factor binding to better understand epigenetic features in chromatin. His current investigations explore the reprogramming of patient cells into various cell types relevant for disease modeling and regenerative medicine, utilizing combinatorial transcription factor delivery methods and single-cell RNA sequencing to identify the combinations of transcription factors that facilitate cellular reprogramming. His research has significant implications for drug and gene screening processes in therapeutic applications.

Research Interests