Dr. Rick Danheiser

Professor

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Biography

Rick Lane Danheiser is a leading figure in the field of chemistry at the Massachusetts Institute of Technology, where he serves as the C Cope Professor in the Department of Chemistry. His research focuses on developing new synthetic methods and strategies for the total synthesis of natural products and biologically significant compounds. A significant thrust of his current investigations is the design and invention of novel cycloaddition and annulation strategies for synthesizing carbocyclic and heterocyclic compounds. His methods involve the application of unusual molecules and highly reactive species as building blocks for constructing important classes of organic compounds. Additionally, he has a keen interest in the chemistry of highly unsaturated conjugated molecules and unusually strained molecules, including arynes, cycloalkynes, and cyclic allenes. His laboratory emphasizes the development of environmentally benign methods of organic synthesis, utilizing supercritical water and carbon dioxide as reaction media to minimize waste byproducts in metal-free synthetic reactions. His past accomplishments include the total synthesis of significant compounds such as the antitumor antibiotic ascochlorin, the azulene antiulcer drug egualen sodium, and neurotoxic alkaloids derived from poison dart frogs. He has also focused on the synthesis of unusual polycyclic aromatic systems with innovative electronic and spectroscopic properties.

Research Interests