Dr. Robert Griffin

Biography

Robert Guy Griffin is the Arthur Amos Noyes Professor of Chemistry at the Massachusetts Institute of Technology. His research primarily focuses on the development of new magnetic resonance techniques for studying molecular structure and dynamics. A significant part of his research efforts is devoted to designing experiments to measure 13C-13C and 13C-15N dipolar couplings, which play a critical role in spectral assignments and measuring internuclear distances and torsion angles in solids. He is actively developing high-field dynamic nuclear polarization (DNP)/NMR experiments to obtain large nuclear spin polarizations, thereby increasing NMR signal intensities for new applications. His work also includes conducting continuous-wave pulsed EPR experiments at 140 GHz to increase resolution and ease the interpretation of spectral lineshapes. Griffin's major contributions involve employing MAS NMR experiments to investigate the structures of large enzyme/inhibitor complexes and membrane proteins, specifically addressing structural questions of inhibitors at active sites. His research has led to significant advancements in the understanding of the molecular structures of amyloid and membrane peptides across various chemical and biophysical problems.

Research Interests

Experience