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As an undergraduate student, I became interested in how biological molecules can change their shape to perform different functions in the cell. This property is crucial for regulating many aspects of human health, and when these dynamics are disrupted, serious diseases can occur. My research focuses on the structural dynamics of biomolecules, emphasizing how these dynamics influence their activity and interactions. In my lab, we study the formation and activation of protein molecular 'machines' such as proteases and nucleases that play vital roles in cellular processes. We utilize a suite of biophysical tools, including isothermal titration calorimetry and nuclear magnetic resonance spectroscopy, to gain a comprehensive understanding of these processes. Our research aims to illuminate the molecular basis of these machines and their implications in health and disease contexts. This work equips our trainees with a well-rounded skillset in experimental and computational methods for biophysical research, preparing them for careers in academic, industry, or government positions. Ultimately, we hope to contribute to the understanding of biomolecular behavior and its significance in biological systems.
University of Guelph • Guelph, Ontario, Canada
Teaching and conducting research in the Department of Molecular and Cellular Biology.
Department of Clinical Studies. Offers MSc by thesis (2 years) and MSc by coursework (1 year).