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Robert Landick is the Laurens Anderson Distinguished Professor in the Department of Biochemistry at the University of Wisconsin-Madison. His research focuses on the structure and function of RNA polymerase (RNAP), a central player in the regulation of gene expression. Landick's lab investigates the intricate regulatory mechanisms that control RNAP activity, as multiple subunits and extrinsic regulators orchestrate its function in transcription. Current projects employ diverse approaches, from molecular genetics to biophysics, to elucidate how these regulators affect RNAP's conformation and its global distribution along genes and operons. Landick is particularly interested in the dynamics of transcriptional regulation in both bacterial and human systems, with ongoing work aimed at understanding the control mechanisms for RNAPII in relation to processes like HIV-1 gene expression, stem cell differentiation, and mRNA processing. His innovative methodologies include single-molecule transcription assays and rapid kinetic assays to dissect the interactions of elongation factors with RNAP.
University of Wisconsin-Madison • Madison, WI
Leading research in the study of RNA polymerase and its regulatory mechanisms.
Department: Department of Computer Sciences