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Dr. Robert Rowe is an Assistant Professor in the Department of Pediatrics at Boston Children's Hospital and is involved in the PhD Program in Biological Biomedical Sciences at Harvard University. His research focuses on the intersection of normal hematopoietic development and blood diseases, addressing how varying properties of the hematopoietic system affect the emergence of these diseases in adults and children. Dr. Rowe's laboratory is dedicated to understanding the cell-intrinsic and extrinsic factors that define the functions of hematopoietic stem and progenitor cells (HSPCs) across different ages. Utilizing mouse and human models, he explores the molecular mechanisms behind HSPC maturation as it relates to prenatal and pediatric conditions compared to adult states. His investigations employ various transplantation models to discern the roles of intrinsic and extrinsic influences on HSPC aging. Furthermore, he aims to apply developmental concepts to better understand blood diseases, which often present differently based on age, including bone marrow failure syndromes, hemoglobinopathies, and subtypes of leukemia. Dr. Rowe is keen on developing novel models to elucidate age-related pathobiology in leukemia and utilizes human induced pluripotent stem cells to investigate factors that differentiate classes of HSPC dysfunction.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).