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Robert W. Sobol is a Professor in the Department of Pathology and Laboratory Medicine at the Warren Alpert Medical School of Brown University, where he also serves as the Associate Director and basic research co-leader of the Cancer Biology Program at the Legorreta Cancer Center. His lab focuses on the role of DNA base excision repair pathway regulation in response to replication stress, specifically through the activation of PARP and the identification of novel targets to overcome PARP-inhibitor resistance. Sobol's research involves developing innovative biological tools and assays to evaluate PARP-activation, the effects of genotoxic stress, and gene-environment interactions. The lab utilizes these tools to analyze tumor responses and the impact of industrial pollutants, aiming to discover molecules that inhibit cellular repair processes. Furthermore, Sobol's work has a translational aspect, examining PARP-dependent DNA damage response pathways and their effects on tumor cell survival, genotoxicity, cellular aging, and responses to chemotherapy and immune checkpoint-based therapies.
Department: Department of Economics