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Robert Weinzierl's research focuses on structure-function relationships of gene-specific transcription factors (GSTFs) and their role in human oncoproteins. These proteins fulfill significant regulatory functions, and their mutations can lead to dysregulated functions in cancer cells. He investigates important oncoproteins, including c-MYC, which is responsible for approximately two-thirds of human cancers. His laboratory conducts extensive computational simulations to understand the structural ensembles of intrinsically disordered proteins (IDPs), which cannot form stable three-dimensional structures like folded proteins. The focus is also on high-throughput robotic approaches to identify transcriptional activation domains and the regions involved in protein-protein interactions within IDPs. His studies aim to provide new insights into the pivotal role of oncoprotein GSTFs under both normal and pathological cellular conditions.
Specialisms available in Materials for the Energy Transition or Theory and Simulation of Materials.