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Roberto Dominguez is the William Maul Measey Presidential Professor in the Department of Physiology at the Perelman School of Medicine, University of Pennsylvania. His research expertise lies in the study of proteins that control actin cytoskeleton and the connections between cytoskeleton and membranes. His laboratory employs a wide range of experimental approaches, including structural biology, biochemistry, and cell biology, to investigate how cytoskeletal proteins govern various essential cellular functions such as cell locomotion, intracellular transport, and endocytosis-exocytosis. Dysfunction in cytoskeletal components can lead to severe diseases, including cancer and neurodegenerative disorders. Dominguez aims to understand the structures and activities of these proteins within the context of protein-protein and protein-membrane interaction networks. A key tool in his research is X-ray crystallography, which provides detailed structural insights but may miss dynamic aspects of protein function. To address these dynamic aspects, he integrates molecular biology, bioinformatics, and various biophysical methods in his investigations.
Department of Physiology, Perelman School of Medicine • University of Pennsylvania
Leading research in the mechanisms by which cytoskeletal proteins influence cellular activities.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.