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Rodger Duffin studies the mechanisms controlling the initiation and resolution of inflammatory processes, with a focus on understanding the potential toxicology surrounding environmental and occupational nanoparticle exposures. His research spans various themes related to inflammation and repair, particularly in the context of chronic inflammatory diseases such as emphysema, bronchitis, and rheumatoid arthritis. Over the past two decades, he has taken an innovative approach by harnessing mechanisms of inflammatory responses to develop novel therapies. Duffin has identified a process by which neutrophils undergo 'suicide' to be removed by macrophages in inflamed sites, a crucial mechanism for resolving inflammation. His recent work, published in 'Nature Medicine', reveals that CDK inhibitor drugs can induce neutrophil suicide in the presence of survival factors, which may lead to the discovery of effective anti-inflammatory drugs. Duffin collaborates with various researchers in the field and has received funding from notable organizations, including the Medical Research Council and the British Heart Foundation.
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