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Ronen Marmorstein, Ph.D., is the George W. Raiziss Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania. He specializes in biochemical and biophysical methodologies, including X-ray crystallography and cryo-electron microscopy (cryo-EM). Marmorstein's research focuses on understanding the molecular mechanisms underlying age-associated diseases, such as cancer and neurodegenerative disorders. His laboratory investigates protein post-translational modifications, particularly acetylation and its regulation, as well as the role of kinases in signaling pathways like MAPK. The lab aims to utilize structural biology to probe protein functions, develop small-molecule inhibitors, and explore the connections between metabolism and epigenetic regulation. Marmorstein has contributed significantly to the understanding of how histone modifications are regulated and their impact on gene expression.
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