Dr. Ruaidhri Carmody

Biography

Ruaidhri Carmody is a Reader in the School of Molecular Biosciences at the University of Glasgow. His research focuses on the NF-κB family of proteins, which have emerged as critical transcription factors related to human health and disease. His work explores the complex regulatory networks surrounding NF-κB activation in the cytoplasm and identifies key nuclear events that dictate the transcriptional outcomes of receptor-activated NF-κB. Significant findings include the identification of Bcl-3 as a major regulator of NF-κB transcriptional activity, particularly in relation to Toll-like receptor signaling. Carmody's research emphasizes the balance between ubiquitination and de-ubiquitination of NF-κB subunits in the nucleus and how this balance affects gene transcription. His studies also contribute to understanding Toll-like receptor tolerance and its implications in limiting inflammation-related tissue damage. Furthermore, his work aims to uncover novel therapeutic targets for inflammatory diseases by revealing fundamental aspects of transcriptional regulation in inflammation. He has been involved in multiple research grants aimed at targeting NF-κB to control vascular injury and exploring its functions within B cells.

Research Interests

Experience