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Rusty Gage is a Professor in the Laboratory of Genetics at the Salk Institute for Biological Studies. His research focuses on age-related neurodegenerative diseases, particularly Alzheimer’s. Gage has made significant contributions to understanding neurogenesis in the adult human brain, demonstrating that new neurons can be formed in response to environmental enrichment and physical exercise. His lab's work with human stem cells aims to model diseases and explore mechanisms that lead to neurological and psychiatric disorders such as depression and autism. Gage's prolific research and discoveries include showing that exercise increases the brain's capacity to generate new neurons and using stem cell technologies to investigate schizophrenia at the cellular level. He leads projects supported by major grants, including a $19.2 million initiative to analyze the interactions between proteins, genes, and epigenetics related to cognitive decline.