Dr. Ryan Jensen

Biography

Ryan Jensen is an Associate Professor in the Department of Therapeutic Radiology at Yale School of Medicine. His research focuses on the BRCA2 gene and its critical role in DNA repair mechanisms, particularly homologous recombination, which is vital for maintaining genomic stability. He has developed methods to purify the full-length BRCA2 protein to better understand its interactions with various proteins involved in DNA damage response. Jensen's lab employs a multi-disciplinary approach combining biochemistry, genetics, and structural biology to elucidate the functional consequences of BRCA2 interactions and their implications in cancer development, especially in hereditary breast and ovarian cancer syndrome. His work aims to uncover the molecular pathogenesis associated with BRCA2 mutations and to identify regulatory mechanisms in DNA repair processes.

Research Interests