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Saba Parvez is an Assistant Professor at Northwestern University Feinberg School of Medicine, specializing in Cell and Developmental Biology. Her research focuses on the fundamental challenges in developmental biology, particularly how the genome regulates animal development. Despite significant progress in understanding key genes and pathways, a systematic understanding of the vast majority of the genome remains lacking, partially due to the absence of tools to perform large-scale genetic manipulations in whole animals. Recent advancements, particularly in CRISPR-Cas9 technology, have opened new avenues for targeted disruption of genomic regions, allowing for high-throughput functional screens. Saba developed a platform known as Multiplexed Intermixed CRISPR Droplets (MIC-Drop), which enables such screenings in zebrafish. The Parvez Lab aims to harness this tool to explore the functions of highly conserved noncoding genomic regions that are crucial for animal development. Additionally, the lab is interested in the molecular mechanisms underpinning congenital developmental disorders and aims to create zebrafish models for genetic disorders to identify novel therapeutics.
Northwestern University Feinberg School of Medicine • Chicago, Illinois
Conduct research in cell and developmental biology, focusing on genomic regulation in animal development.
Administered by The Graduate School; focuses on Biomechanics, Imaging, Biomaterials, and Regenerative Medicine.