Generate a tailored SOP for Dr. Sahin Naqvi. Improve your application with a focused, well-structured draft.
Sahin Naqvi is an Assistant Professor in the PhD Program in Biological Biomedical Sciences at Harvard University. His research focuses on gene expression control and its fundamental role in biological systems, particularly through transcription factors (TFs) that bind to specific DNA sequences. His work is aimed at understanding the quantitative aspects of transcription factor levels, which are critical in rare disorders and influence common diseases. The Naqvi lab employs innovative approaches to manipulate TF dosage in human pluripotent stem cells, developing methods to enable bidirectional tuning of TF levels. They investigate the implications of TF dosage sensitivity specifically in human neural crest development, which is a multipotent embryonic population linked to various developmental disorders, including craniofacial malformations. Additionally, the lab integrates deep learning techniques to decode regulatory mechanisms and to enhance the predictive understanding of how TF dosage impacts gene responsiveness. Their research offers valuable insights into the molecular underpinnings of development and disease.
Boston Children's Hospital • Boston, MA
Research and teaching in the field of Biological Biomedical Sciences with a focus on gene expression control and transcription factors.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).